Beilstein J. Org. Chem.2018,14, 2321–2330, doi:10.3762/bjoc.14.207
and costs were significantly reduced. In addition, a variety of D-forosaminereplacement analogues of spinetoram J were synthesized based on the improved semi-synthesis, and their insecticidal activities were evaluated against third-instar larvae of Plutella xylostella. Although none of the analogues
products with other groups, and the improved semi-synthesis will be helpful for further researches on spinetoram.
Keywords: analogues; forosaminereplacement; improved semi-synthesis; insecticide; natural products; spinetoram; Introduction
Nowadays, insect pests are one of the primary hazards that affect
were no reports about the chemical modification of spinetoram. Therefore, in this study, a series of D-forosaminereplacement analogues of spinetoram J were synthesized based on the improved semi-synthesis (Scheme 3), and the insecticidal activities of analogues were evaluated against third-instar